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M9630526.TXT
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1996-02-27
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Document 0526
DOCN M9630526
TI Distribution of baboon endogenous virus among species of African monkeys
suggests multiple ancient cross-species transmissions in shared
habitats.
DT 9603
AU van der Kuyl AC; Dekker JT; Goudsmit J; Human Retrovirus Laboratory,
Academic Medical Centre, Amsterdam,; The Netherlands.
SO J Virol. 1995 Dec;69(12):7877-87. Unique Identifier : AIDSLINE
GENBANK/X51929
AB PCR amplification of baboon endogenous virus (BaEV) long terminal
repeat, reverse transcriptase gene, and env fragments from 24 different
species of African monkeys indicates that BaEV is less widespread than
was formerly thought. Instead of being present in every species of
African primates, BaEV can be found only in baboons, geladas, and
mangabeys (all belonging to the Papionini tribe) and in African green
monkey (Cercopithecus aethiops)subspecies. BaEV, which can be activated
from baboon and gelada tissues, was most likely introduced in the germ
line only recently (less than a few million years ago) and has not been
inherited from a common ancestor of all extant African monkeys.
Neighbor-joining and maximum-likelihood analyses of the sequences
obtained showed that two distinct virus clusters can be distinguished:
the first containing baboon, gelada, and African green monkey BaEV
sequences and the second consisting of mandrill and mangabey BaEV
sequences. This viral evolutionary tree does not follow host phylogeny,
indicating the cross-species transmissions and multiple germ line
fixations of the virus must have occurred in the past. BaEV sequences
are found in monkeys inhabiting savannas (baboons, geladas, and African
green monkeys) as well as forests (managabeys and mandrills) and cluster
according to the habitats of their hosts, providing evidence for
cross-species transmission in shared habitats.
DE Amino Acid Sequence Animal Base Sequence Cercopithecidae/*VIROLOGY
Cercopithecus aethiops/*VIROLOGY Comparative Study DNA Primers DNA,
Viral/BLOOD/GENETICS/ISOLATION & PURIF Genes, env Molecular Sequence
Data Papio/*VIROLOGY *Phylogeny Polymerase Chain Reaction Repetitive
Sequences, Nucleic Acid
Retroviridae/CLASSIFICATION/*GENETICS/*ISOLATION & PURIF RNA-Directed
DNA Polymerase/CHEMISTRY/*GENETICS Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid Social Behavior Species Specificity
Support, Non-U.S. Gov't Theropithecus gelada/VIROLOGY Viral Envelope
Proteins/CHEMISTRY/*GENETICS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).